Chuck Pagano has been fired as head coach of the Indianapolis Colts.

The Colts made the announcement after the team’s season-ending 22-13 win over the Houston Texans.

The Colts finished with a 4-12 record, the worst mark of Pagano’s six-year tenure, with the team missing the playoffs for a third consecutive season.

“Chuck Pagano provided Colts fans with many exciting wins and memories as head coach of the Colts,” Colts owner Jim Irsay said in a statement. “Throughout his tenure in Indianapolis, he impacted the lives of the players he coached, those who he worked with in the organization and Colts fans across the globe."

Much of the Colts’ dip in fortunes in recent seasons is due to the health of franchise quarterback Andrew Luck. After appearing in only 22 games over the past two seasons, Luck did not dress in 2017 following an operation on his throwing shoulder for an issue lingering since the 2015 season. Jacoby Brissett, acquired from the New England Patriots during the exhibition season, has served as starting QB since Week 2.

A native of Boulder, CO, Pagano joined the Colts in 2012 from the Baltimore Ravens where he served as defensive coordinator. His first season with the team was interrupted, though, when he was diagnosed with leukemia and left the team for treatment in Week 5. Pagano returned in time for Week 16 and an AFC Wild Card playoff game.

"Chuck’s first season was one of the more inspirational stories in NFL history as he courageously battled and overcame leukemia," Irsay said. "As a result, his CHUCKSTRONG Foundation has raised millions for cancer research. We are thankful for Chuck’s contributions to our franchise and community and we wish him, Tina and the entire Pagano family nothing but the best moving forward.”

Pagano then posted identical 11-5 records in 2013 and 2014, finishing atop the AFC South. In both seasons, though, the Colts’ postseason runs came to an end at the hands of the New England Patriots.

Pagano finishes his tenure with 53 wins, good for fourth-most in team history.

The Colts will draft with the third overall selection in April's NFL Draft.