Vladimir Guerrero Jr. has done it again.

The Toronto Blue Jays slugger hit a third-inning home run for his 25th of the season, re-taking the American League homer lead all by himself after Shohei Ohtani led off Friday's game at Tropicana with his 24th. 

Guerrero took a 95 MPH fastball from Baltimore's Matt Harvey deep and gone to centre field, giving the Jays a 2-1 lead over the Orioles in the second inning. Guerrero also homered in Thursday night's 9-0 victory over the Orioles in the first of their four-game series.

Guerrero came into the game hitting .338 with an on-base percentage of .441 and a slugging percentage of .669.

The Blue Jays (38-35) will continue their series with the Orioles (23-52) at Sahlen Field in Buffalo over the weekend.